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GT Biopharma Company Update

Joe Samuel

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TAMPA, Florida, June 10, 2019 /PRNewswire/ — GT Biopharma, Inc. (GTBP) (GTBP.PA) an immuno-oncology company focused on innovative treatments based on the Company’s proprietary NK cell engager (TriKE) platform and Multi-Target Directed Bispecific Drug Conjugate (MTBDC) platform, today provided an update of the company’s drug development programs.

GT Biopharma continues to move forward with its development of the HIV TriKE. On April 24th GT Biopharma announced the elimination of HIV infected cells using its Tri: Specific Killer Engagers (TriKEs) in Preclinical Testing at the University of Minnesota. Which could represent a possible cure to HIV which now has over 35 million infected people worldwide.

About the HIV TriKE

In preclinical testing led by Dr. Jeffrey Miller, M.D., Deputy Director Masonic Cancer Center and Dr. Timothy Schacker, M.D., Medical School and Director, Program in HIV Medicine, the research team designed a series of Bispecific and Trispecific Natural Killer Cell Engagers (BiKE and TriKE) constructs to direct Natural Killer cell mediated cytotoxicity against an HIV infected target. The data demonstrate that a BiKE construct can eliminate HIV infected targets expressing the HIV envelope on their surface. Based on the success of the BiKE data, GT Biopharma is planning to develop a TriKE version by incorporating IL-15 into the BiKE scFv construct to increase the level of NK cell killing of targeted HIV infected cells.

Additional TriKEs (Trispecific NK cell engagers) which target hematological malignancies (liquid tumors), and solid tumor cancers, are also progressing under the TriKE platform. The TriKE platform’s ability to expand into solid tumors (80% of the cancer market) allows for a much more economical and wider approach then CAR-T. Most recently KITE Pharma was bought by Gilead Sciences, Inc. for $12 Billion (GILD) and Juno Therpeautics was accuried ($9 Billion) by Celegene Corporation (CELG). These highly expensive cell therapies are limited to only liquid tumors (20% of the cancer market). The TriKE off the shelf technology is a protein (drug) version of CAR-T using the TriKE’s ability to employ NK (Natural Killer) cells from the immune system as the catalyst to target, attack and kill specific cancers.

GTB-3550 (OXS-3550) is the Company’s first Tri-specific NK cell Engager (TriKE) product candidate being initially developed for the treatment AML. GTB-3550 (OXS-3550) is being readied to begin enrolling patients with advanced Acute Myeloid Leukemia (AML) in a Phase I/II expansion clinical trial starting mid- July 2019.

About GTB-3550 Trispecific NK cell Engager (TriKE)

GTB-3550 is a single-chain, tri-specific scFv recombinant fusion protein conjugate composed of the variable regions of the heavy and light chains of anti-CD16 and anti-CD33 antibodies and a modified form of IL-15.  The natural killer (NK) cell stimulating cytokine human IL-15 portion of the molecule provides a self-sustaining signal that activates NK cells and enhances their ability to kill.  We intend to study GTB-3550 in CD33 positive leukemias such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and other CD33+ hematopoietic malignancies.

GTB-1550 (DT2219) top-line Phase I/II expansion clinical trial results have been promising; two patients exhibited a complete remission (CR) with one patient currently disease-free at 50 months post completion of the study. A Phase 2 study is being planned.

About GTB-1550 Multi-Target Directed Bispecific Drug Conjugate

GTB-1550 targets cancer cells expressing the CD19 receptor or CD22 receptor or both receptors thereby maximizing cancer cell recognition by binding to CD19+, CD22+ and CD19+/CD22+ cancer cells.  When GTB-1550 binds to cancer cells, the cancer cells internalize GTB-1550, and are killed due to the action of drug’s cytotoxic diphtheria toxin payload.

Mr. Anthony Cataldo, the Chairman and Chief Executive Officer of GT Biopharma, commented, “­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­We are pleased with the progress of our clinical development programs.” The HIV TriKE’s possibility to kill the HIV virus would solve a massive economic burden as well as stop infected patients from spreading the disease. Mr. Cataldo also noted that the Company has two key platform technologies to attack cancer:  the TriKE platform, and the Multi-Targeted Directed Bispecific Cytotoxic Payload platform.  Mr. Cataldo stated, “We believe that these Platform technologies present first-in-class therapeutic opportunities for the Company, and will be the main focus going forward.”

About GT Biopharma, Inc.

GT Biopharma, Inc. is a clinical stage biopharmaceutical company focused on the development and commercialization of immuno-oncology products based off our proprietary Tri-specific Killer Engager (TriKE) and Multi-Target Directed Bispecific Drug Conjugate (MTBDC) technology platforms.  Our TriKE platform is designed to harness and enhance the cancer killing abilities of a patient’s immune system natural killer cells (NK cells).  GT Biopharma has an exclusive worldwide license agreement with the University of Minnesota to further develop and commercialize cancer therapies using proprietary TriKE technology developed by researchers at the university to target NK cells to cancer.  Our Multi-Target Directed Bispecific Drug Conjugate (MTBDC) platform can generate product candidates that are bi-specific, ligand-directed single-chain fusion proteins that, we believe, represent the next generation of targeted therapy.

Forward-Looking Statements

This press release contains certain forward-looking statements that involve risks, uncertainties and assumptions that are difficult to predict, including statements regarding the potential acquisition, the likelihood of closing the potential transaction, our clinical focus, and our current and proposed trials.  Words and expressions reflecting optimism, satisfaction or disappointment with current prospects, as well as words such as “believes”, “hopes”, “intends”, “estimates”, “expects”, “projects”, “plans”, “anticipates” and variations thereof, or the use of future tense, identify forward-looking statements, but their absence does not mean that a statement is not forward-looking.  Our forward-looking statements are not guarantees of performance and actual results could differ materially from those contained in or expressed by such statements. In evaluating all such statements, we urge you to specifically consider the various risk factors identified in our Form 10-K for the fiscal year ended December 31, 2018 in the section titled “Risk Factors” in Part I, Item 1A and in our subsequent filings with the Securities and Exchange Commission, any of which could cause actual results to differ materially from those indicated by our forward-looking statements.

Our forward-looking statements reflect our current views with respect to future events and are based on currently available financial, economic, scientific, and competitive data and information on current business plans. You should not place undue reliance on our forward-looking statements, which are subject to risks and uncertainties relating to, among other things:  (i) the sufficiency of our cash position and our ongoing ability to raise additional capital to fund our operations, (ii) our ability to complete our contemplated clinical trials for GTB-3550 or GTB-1550, or to meet the FDA’s requirements with respect to safety and efficacy, (iii) our ability to identify patients to enroll in our clinical trials in a timely fashion, (iv) our ability to achieve approval of a marketable product, (v) design, implementation and conduct of clinical trials, (vii) the results of our clinical trials, including the possibility of unfavorable clinical trial results, (vii) the market for, and marketability of, any product that is approved, (viii) the existence or development of treatments that are viewed by medical professionals or patients as superior to our products, (ix) regulatory initiatives, compliance with governmental regulations and the regulatory approval process, and social conditions, and (x) various other matters, many of which are beyond our control. Should one or more of these risks or uncertainties develop, or should underlying assumptions prove to be incorrect, actual results may vary materially and adversely from those anticipated, believed, estimated, or otherwise indicated by our forward-looking statements.

We intend that all forward-looking statements made in this press release will be subject to the safe harbor protection of the federal securities laws pursuant to Section 27A of the Securities Act, to the extent applicable. Except as required by law, we do not undertake any responsibility to update these forward-looking statements to take into account events or circumstances that occur after the date of this press release. Additionally, we do not undertake any responsibility to update you on the occurrence of any unanticipated events which may cause actual results to differ from those expressed or implied by these forward-looking statements.

Pursuant to an agreement between MIDAM VENTURES, LLC and GT Biopharma, Midam was hired for a period from 06/07/2019 – 7/07/2019 to publicly disseminate information about GT Biopharma including on the Website and other media including Facebook and Twitter. We were paid $100,000 (CASH) for & were paid “0” shares of restricted common shares. We may buy or sell additional shares of GT Biopharma in the open market at any time, including before, during or after the Website and Information, provide public dissemination of favorable Information.

For more information, please visit www. gtbiopharma . com.

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The Roller Coaster Ride On Shutterfly (SFLY) Stock

Joe Samuel

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shutterfly acquisition

Shutterfly (SFLY) has been one of the most important companies in the photofinishing industry with the range of services that it offered. Over the past twenty years, the company had been involved in services like digital photo storage, customized merchandise, and print processing among others. However, the company is now all set to make an exit from the business that they have built up over the years by selling it to Apollo Global Management.

Acquisition News

Last week, the company announced that it had accepted the offer that had been made by Apollo and some experts claim that the investors in Shutterfly might not be entirely happy with the final payout.

[REPORT] Two Massive Growth Industries, One Choice for Investors

Apollo is going to fork out $51 per share for the acquisition and that might not make many investors happy, considering the fact that it is just 1.5% higher than the closing price of the Shutterfly stock on Monday. However, there is another way of looking at it.

The news of a potential acquisition by Apollo had first been reported back on 23 April and it was then that the stock started climbing. If the price prior to that surge is taken into consideration, then the shareholders are looking at a 31% premium on their shares.

What Are Investors Saying?

That being said, the investors still have a lot to be upset about, since Shutterfly stock had been trading at $100 on June 5 last year. However, it is quite clear that the price offered by Apollo is the best deal since no other bidder has come forward with a counteroffer. Apollo will be paying out $2.7 billion for the acquisition.

Shutterfly’s business started showing weaknesses towards the end of last year and the company’s acquisitions at the time did not really make a big dent in the revenues. Although the business has shown weaknesses, it is important to note that Apollo clearly sees a future in the company; otherwise, it would not have forked out $2.7 billion for the company.

While the company will continue to be in business, it has been a pretty harrowing experience for people who had invested in the company.

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Stock Price Mid-Day Update

Jon Phillip

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What a way to start the week.  The markets are green right now and even ahead of all of the expected financial meetings this week, sentiment is high.  That’s true too for the companies we talked about this morning. So let’s dive in and get everyone caught up to speed.

ParcelPal Technology Inc. (PKG.CN) (PTNYF) Jumps On Integration News

ParcelPal Technology Inc. (PKG.CN) (PTNYF) has been on the move for most of the month and the recent jump comes on the heels of this penny stock announcing integration on the Shopify platform. If you’re wondering, this is the same Shopify that trades publicly at OVER $300 a share!

Now the deal was first scooped by Benzinga and was later confirmed when ParcelPal formally announced the deal later in morning. Businesses of any kind, notably cannabis merchants will be able to integrate their Shopify eCommerce store nearly instantly to ParcelPal’s ecosystem.

These merchants will enable their customers to tap into ParcelPal’s network and have their products delivered in an hour or less. ParcelPal has begun this process with Choom and Kiaro. You can read more about the ParcelPal/Shopify News Here. Since June 3, ParcelPal is up by more than 35% and we, for one, will continue to bring more updates as we find them.

GT Biopharma, Inc. (GTBP) Consolidation Could Lead To More Excitement

GT Biopharma, Inc. (GTBP) continues to pick up the pace.  Since we initiated coverage on the company, we’ve watch GTBP climb as much as 30% and as of today, it’s still up by roughly 12.5% in just over a week. We have seen a bit of consolidation to start this week but that could open the door to more excitement in June. The big focus for GTBP onlookers has been on its immunotherapy portfolio.

The bottom line here is that big money is pouring into cancer-focused companies specifically. The fact that as we write this, Pfizer is in the middle of an $11 billion dollar deal to buy a cancer therapy company should be even more proof of this focus.

To date, GT Biopharma has completed one dose escalation Phase I-II expansion clinical trial, and one fixed dose Phase I-II expansion clinical trial, which collectively enrolled a combined 43 patients. On the surface, the Phase I-II expansion clinical trial demonstrated greater than 50% of Evaluable patients receiving 60 mg/kg dose had a positive clinical response.

Two patients exhibited a Complete Remission with one patient currently disease-free at 50 months post-treatment. Additionally, five patients exhibited Stable Disease, cancers that are neither increasing nor decreasing in severity, with the longest response lasting 12 months post-treatment. In addition to this, the company’s therapy has also shown that it could target HIV infected cells in the University of Minnesota’s preclinical testing. Not only that but in specific tests, data showed that HIV-infected targets that express the HIV envelope on their surface could be eliminated. We’ve put together a full report on GTBP so click here for more info.

Liberty Defense Holdings, Ltd. (SCAN.V) Surges On German Deal

We brought this back to the attention of our members earlier last week and since then things have been quite exciting to say the least. Here’s why: Liberty Defense was trading at CAD$0.69 and today we’ve witnessed a big boom to highs of $0.85 after making another big MOU announcement.  What was the news? Liberty Defense (SCAN.V) will be collaborating with FC Bayern München to beta test HEXWAVE. You can read the whole PR here.

This is what Bill Riker, CEO of Liberty Defense, said about this deal, “The reception to our HEXWAVE product has been fantastic and we are excited about working alongside FC Bayern Munich, a team that is a household name in both Europe and North America. Our ability to deploy in both indoor and outdoor settings, with covert and overt applications, sets us apart and has also been driving increasing interest from the market.”

stock price today
Disclaimer: MIDAM VENTURES LLC has been compensated $75,000 per month by a ParcelPal Technology, Inc. for a period beginning September 1, 2018 and ending February 1, 2019 to publicly disseminate information about (PTNYF/PKG) to publicly disseminate information about (PTNYF/PKG). Midam Ventures has been compensated $100,000 by Parcel Pal and has extended coverage to April 1, 2019. Midam Ventures has been compensated $100,000 by Parcel Pal and has extended coverage to May 1, 2019. Midam Ventures has been compensated $200,000 by Parcel Pal and has extended coverage to June 1, 2019. Midam Ventures has been compensated $200,000 by Parcel Pal and has extended coverage to July 1, 2019. We may buy or sell additional shares of (PTNYF/PKG) in the open market at any time, including before, during or after the Website and Information, provide public dissemination of favorable Information. We own zero shares.

Pursuant to an agreement between MIDAM VENTURES, LLC and GT Biopharma, Midam was hired for a period from 06/07/2019 – 7/07/2019 to publicly disseminate information about GT Biopharma including on the Website and other media including Facebook and Twitter. We were paid $100,000 (CASH) for & were paid “0” shares of restricted common shares. We may buy or sell additional shares of GT Biopharma in the open market at any time, including before, during or after the Website and Information, provide public dissemination of favorable Information.

Pursuant to an agreement between MIDAM VENTURES, LLC and Liberty Defense Holdings Inc. Midam was hired for a period from 04/15/2018 – 5/15/2019 to publicly disseminate information about Liberty Defense Holdings Inc. including on the Website and other media including Facebook and Twitter now extended through June 21, 2019. We were paid $350,000 (CASH) for & were paid “0” shares of restricted common shares. We may buy or sell additional shares of Liberty Defense Holdings Inc. in the open market at any time, including before, during or after the Website and Information, provide public dissemination of favorable Information.

 Click Here For Full Disclaimer

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Stock Price Monday Morning Update – June 17, 2019

Joe Samuel

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ParcelPal (PKG.CN) (PTNYF) & Shopify (SHOP) Integration Opening Big Doors For Cannabis In Canada

Originally scooped by Benzinga (see: Scoop: Shopify And ParcelPal To Integrate For Cannabis Delivery In Canada), ParcelPal has formally announced that it will be integrating with Shopify to offer cannabis products to customers of Shopify shops. This will be available in Vancouver, Calgary, and Saskatchewan. Customers ordering from Shopify stores in these areas will be able to receive cannabis at their own homes.

Click For Full Coverage


Liberty Defense (SCAN.V) to Collaborate with FC Bayern München to Beta Test HEXWAVE

VANCOUVER and MÜNCHEN, Germany, June 17, 2019 /PRNewswire/ – Liberty Defense Holdings, Ltd. (“Liberty”) (TSXV: SCAN; FRANKFURT: LD2), a leader in security and weapons detection solutions, is pleased to announce that the company has signed a Memorandum of Understanding (“MOU”) with the German soccer team, FCBayern München (“FC Bayern”), a German football club based in Munich, Bavaria (“Bayern”) to beta test HEXWAVE.

Click For Full Release


Big Investments Are Signaling The Green Light For A ‘Hot Market’ With Cancer-Fighting Stocks

If you’ve ever invested in the stock market or traded a single share, chances are you’ve familiarized yourself with the “hot markets”. These are the ones that consistently see enormous volatility and gains that most only dream of.

See For Yourself


Disclaimer: MIDAM VENTURES LLC has been compensated $75,000 per month by a ParcelPal Technology, Inc. for a period beginning September 1, 2018 and ending February 1, 2019 to publicly disseminate information about (PTNYF/PKG) to publicly disseminate information about (PTNYF/PKG). Midam Ventures has been compensated $100,000 by Parcel Pal and has extended coverage to April 1, 2019. Midam Ventures has been compensated $100,000 by Parcel Pal and has extended coverage to May 1, 2019. Midam Ventures has been compensated $200,000 by Parcel Pal and has extended coverage to June 1, 2019. Midam Ventures has been compensated $200,000 by Parcel Pal and has extended coverage to July 1, 2019. We may buy or sell additional shares of (PTNYF/PKG) in the open market at any time, including before, during or after the Website and Information, provide public dissemination of favorable Information. We own zero shares.

Pursuant to an agreement between MIDAM VENTURES, LLC and Liberty Defense Holdings Inc. Midam was hired for a period from 04/15/2018 – 5/15/2019 to publicly disseminate information about Liberty Defense Holdings Inc. including on the Website and other media including Facebook and Twitter now extended through June 21, 2019. We were paid $350,000 (CASH) for & were paid “0” shares of restricted common shares. We may buy or sell additional shares of Liberty Defense Holdings Inc. in the open market at any time, including before, during or after the Website and Information, provide public dissemination of favorable Information. Click Here For Full Disclaimer

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